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Medications

Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir Extended Release Oral Tablets

What is this medicine?

DASABUVIR; OMBITASVIR; PARITAPREVIR; RITONAVIR (da sa' bue vir; om bit' as vir; par'' i ta' pre vir; ri toe' na veer) is a combination of four medicines. It is used to treat hepatitis C. It will not work for colds, flu, or other viral infections.

How should I use this medicine?

Take this medicine by mouth with a full glass of water. Follow the directions on the prescription label. Take this medicine with food. Do not cut, crush or chew this medicine. Take your medicine at regular intervals. Do not take your medicine more often than directed. Take all of your medicine as directed even if you think you are better. Do not skip doses or stop your medicine early.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; nausea; confusion; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • itching

  • nausea

  • rash

  • tiredness

  • trouble sleeping

What may interact with this medicine?

Do not take this medicine with the following medication:

  • alfuzosin

  • alcohol

  • atorvastatin

  • carbamazepine

  • cisapride

  • colchicine

  • dronedarone

  • efavirenz

  • ergot alkaloids like dihydroergotamine, ergonovine, ergotamine, methylergonovine

  • everolimus

  • female hormones, like estrogens and birth control pills, patches, rings, or injections

  • gemfibrozil

  • lovastatin

  • lumacaftor; ivacaftor

  • lurasidone

  • midazolam

  • phenytoin

  • phenobarbital

  • pimozide

  • ranolazine

  • rifampin

  • sildenafil

  • simvastatin

  • sirolimus

  • St. John's wort (Hypericum perforatum)

  • tacrolimus

  • triazolam

This medicine may also interact with the following medications:

  • acetaminophen; hydrocodone

  • alprazolam

  • amlodipine

  • antiviral medicines for HIV or AIDS

  • buprenorphine/naloxone

  • candesartan

  • certain medicines for irregular heart beat like amiodarone, bepridil, diltiazem, disopyramide, flecainide, lidocaine, mexiletine, propafenone, quinidine

  • carisoprodol

  • cyclobenzaprine

  • cyclosporine

  • diazepam

  • fluticasone

  • furosemide

  • ketoconazole

  • losartan

  • metformin

  • nifedipine

  • omeprazole

  • pravastatin

  • quetiapine

  • rosuvastatin

  • salmeterol

  • valsartan

  • verapamil

  • voriconazole

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature below 30 degrees C (86 degrees F). Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • HIV or AIDS

  • other liver disease

  • an unusual or allergic reaction to dasabuvir, ombitasvir, paritaprevir, ritonavir, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

See your doctor or health care professional for a follow-up visit as directed. You may need blood work while you are taking this medicine. Tell your doctor if your symptoms do not improve or if they get worse.

If you have had hepatitis B infection (HBV) in the past, taking this medicine could cause the HBV to become active again. If you have had HBV, your doctor should monitor you with blood tests. Tell your doctor right away if you develop a general ill feeling, light-colored stools, loss of appetite, unusual weakness, or yellowing of the eyes or skin.


NOTE:This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Copyright© 2017 Elsevier