West Valley Medical Center Close Window
Library Search Go Advanced Search
Español (Inicio)

Medications

Olanzapine injection (extended-release)

What is this medicine?

OLANZAPINE (oh LAN za peen) is used to treat schizophrenia.

How should I use this medicine?

This medicine is for injection into a muscle by a health care professional. It will be given at regular intervals. Do not stop taking except on the advice of your doctor or health care professional.

Before treatment, you must register in the Zyprexa Relprevv Patient Care Program. Read the Medication Guide that comes with your injection before you start taking it and each time before you receive an injection. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • anxious

  • breathing problems

  • confusion

  • difficulty in speaking or swallowing

  • dizziness

  • excessive drowsiness

  • excessive thirst and/or hunger

  • fainting

  • fast heartbeat (palpitations)

  • fever or chills, sore throat

  • fever with rash, swollen lymph nodes, or swelling of the face

  • frequently needing to urinate

  • inability to control muscle movements in the face, hands, arms, or legs

  • increase in blood pressure

  • irritable or angry

  • irritation at site where injected

  • pain at site where injected

  • painful or prolonged erections

  • redness, blistering, peeling or loosening of the skin, including inside the mouth

  • restlessness or need to keep moving

  • seizures (convulsions)

  • stiffness, spasms

  • tremors or trembling

  • trouble walking

  • weakness

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • changes in sexual desire

  • constipation

  • lowered blood pressure

  • weight gain

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • certain antibiotics like grepafloxacin and sparfloxacin

  • certain phenothiazines like chlorpromazine, mesoridazine, and thioridazine

  • cisapride

  • clozapine

  • droperidol

  • halofantrine

  • levomethadyl

  • pimozide

This medicine may also interact with the following medications:

  • carbamazepine

  • charcoal

  • fluvoxamine

  • levodopa and other medicines for Parkinson's disease

  • medicines for diabetes

  • medicines for high blood pressure

  • medicines for mental depression, anxiety, other mood disorders, or sleeping problems

  • omeprazole

  • rifampin

  • ritonavir

  • tobacco from cigarettes

What if I miss a dose?

Contact your health care provider as soon as possible if you miss an appointment for your injection.

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • breast cancer or history or breast cancer

  • cigarette smoker

  • dementia

  • diabetes mellitus, high blood sugar or a family history of diabetes

  • difficulty swallowing

  • glaucoma

  • heart disease, irregular heartbeat, or previous heart attack

  • high cholesterol

  • history of brain tumor or head injury

  • kidney or liver disease

  • low blood pressure or dizziness when standing up

  • Parkinson's disease

  • prostate trouble

  • seizures (convulsions)

  • stroke

  • suicidal thoughts, plans, or attempt by you or a family member

  • an unusual or allergic reaction to olanzapine, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Your condition will be monitored carefully while you are receiving this medicine. Visit your doctor or health care professional for regular checks on your progress. It may be several weeks before you see the full effects of this medicine. Notify your doctor or health care professional if your symptoms get worse, if you have new symptoms, if you are having an unusual effect from this medicine, or if you feel out of control, very discouraged or think you might harm yourself or others.

After your injection, you will need to stay at the clinic where you receive the injection for at least 3 hours so the doctor can make sure you do not have symptoms of Post-injection Delirium Sedation Syndrome (PDSS). PDSS is a serious problem that can happen if the medicine gets into your blood too fast. Some symptoms of PDSS include drowsiness, dizziness, feeling confused, having trouble talking or walking, seizures, having stiff or shaking muscles, feeling weak, being anxious or angry, passing out or fainting, and having blood pressure changes. When you leave the clinic, someone must be with you. If you have symptoms of PDSS after you leave the clinic or hospital, get medical help right away.

Do not drive or use heavy machinery for the rest of the day after receiving your injection. You may get dizzy or drowsy. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

Do not suddenly stop taking this medicine. You may need to gradually reduce the dose. Ask your doctor or health care professional for advice.

Do not treat yourself for colds, diarrhea or allergies without asking your doctor or health care professional for advice. Some ingredients can increase possible side effects.

If you notice an increased hunger or thirst, different from your normal hunger or thirst, or if you find that you have to urinate more frequently, you should contact your health care provider as soon as possible. You may need to have your blood sugar monitored. This medicine may cause changes in your blood sugar levels. You should monitor you blood sugar frequently if you have diabetes.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water will help. Contact your doctor if the problem does not go away or is severe.

This medicine can reduce the response of your body to heat or cold. Dress warm in cold weather and stay hydrated in hot weather. If possible, avoid extreme temperatures like saunas, hot tubs, very hot or cold showers, or activities that can cause dehydration such as vigorous exercise.

If you smoke, tell your doctor if you notice this medicine is not working well for you. Talk to your doctor if you are a smoker or if you decide to stop smoking.


NOTE:This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Copyright© 2017 Elsevier